Drug Development:

Nuggehally R Srinivas

Role of Stereoselective Assays in Bioequivalence Studies of Racemic Drugs: Have We Reached a Consensus?
J Clin Pharmacol 2004 44: 115. [Abstract] [Full Text] [PDF]  

Drug Metabolism:

Honghui Zhou, Zeen Tong, and James F. McLeod

"Cocktail" Approaches and Strategies in Drug Development: Valuable Tool or Flawed Science?
J Clin Pharmacol 2004 44: 120. [Abstract] [Full Text] [PDF]  

HongXia Zheng, Adriana Zeevi, Erin Schuetz, Jatinder Lamba, Kenneth McCurry, Bartley P. Griffith, Steven Webber, Julianne Ristich, James Dauber, Aldo Iacono, Wayne Grgurich, Diana Zaldonis, Kevin McDade, Jiong Zhang, and Gilbert J. Burckart

Tacrolimus Dosing in Adult Lung Transplant Patients Is Related to Cytochrome P4503A5 Gene Polymorphism
J Clin Pharmacol 2004 44: 135. [Abstract] [Full Text] [PDF]  

Education Series:

P. Timothy Pollak and Steven L. Shafer

Teaching Application of Clinical Pharmacology Skills Using Unusual Observations from Clozapine Overdoses
J Clin Pharmacol 2004 44: 141. [Abstract] [Full Text] [PDF]  

Clinical Studies:

James P. Tsikouris, Jose A. Suarez, Gary E. Meyerrose, Martin Ziska, David Fike, and Jack Smith

Questioning a Class Effect: Does ACE Inhibitor Tissue Penetration Influence the Degree of Fibrinolytic Balance Alteration following an Acute Myocardial Infarction?
J Clin Pharmacol 2004 44: 150. [Abstract] [Full Text] [PDF]  

Pharmacokinetics and Pharmacodynamics:

Bin Peng, Catherine Dutreix, Gunther Mehring, Michael J. Hayes, Monique Ben-Am, Michael Seiberling, Rolf Pokorny, Renaud Capdeville, and Peter Lloyd

Absolute Bioavailability of Imatinib (Glivec®) Orally versus Intravenous Infusion
J Clin Pharmacol 2004 44: 158. [Abstract] [Full Text] [PDF]  

Dietrich Türck, Werner Weber, Ralf Sigmund, Klemens Budde, Hans-H. Neumayer, Lutz Fritsche, Karl-Ludwig Rominger, Ulrich Feifel, and Torsten Slowinski

Pharmacokinetics of Intravenous, Single-Dose Tiotropium in Subjects with Different Degrees of Renal Impairment
J Clin Pharmacol 2004 44: 163. [Abstract] [Full Text] [PDF]  

Steve K. Teo, Michael R. Scheffler, Anfan Wu, David I. Stirling, Steve D. Thomas, Daria Stypinski, and Vikram D. Khetani

A Single-Dose, Two-Way Crossover, Bioequivalence Study of Dexmethylphenidate HCl with and without Food in Healthy Subjects
J Clin Pharmacol 2004 44: 173. [Abstract] [Full Text] [PDF]  

Suresh Mallikaarjun, Daniel E. Salazar, and Steven L. Bramer

Pharmacokinetics, Tolerability, and Safety of Aripiprazole following Multiple Oral Dosing in Normal Healthy Volunteers
J Clin Pharmacol 2004 44: 179. [Abstract] [Full Text] [PDF]  

Pediatrics:

Guy W. Amsden, David P. Nicolau, Anne-Marie Whitaker, Dana Maglio, Akintunde Bello, Rene Russo, Anthony Barros, Jr., and Diptee A. Gajjar

Characterization of the Penetration of Garenoxacin into the Breast Milk of Lactating Women
J Clin Pharmacol 2004 44: 188. [Abstract] [Full Text] [PDF]  

Drug Interactions:

Graham Scott, Linda Yih, Ching-Ming Yeh, Slavica Milosavljev, Aziz Laurent, and Christiane Rordorf

Lumiracoxib: Pharmacokinetic and Pharmacodynamic Profile When Coadministered with Fluconazole in Healthy Subjects
J Clin Pharmacol 2004 44: 193. [Abstract] [Full Text] [PDF]  

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