Editorials:

Lisa L. von Moltke

Clinical Pharmacology and Drug Safety
J Clin Pharmacol 2005 45: 370. [Full Text] [PDF]  

Special Review/Commentary:

Cedric M. Smith

Origin and Uses of Primum Non Nocere—Above All, Do No Harm!
J Clin Pharmacol 2005 45: 371. [Abstract] [Full Text] [PDF]  

Drug Safety:

Manfred Hauben and Lester Reich

Potential Utility of Data-Mining Algorithms for Early Detection of Potentially Fatal/Disabling Adverse Drug Reactions: A Retrospective Evaluation
J Clin Pharmacol 2005 45: 378. [Abstract] [Full Text] [PDF]  

Pharmacoepidemiology:

Nayan V. Acharya, Ruth M. Pickering, Lynda W. Wilton, and Saad A. W. Shakir

The Safety and Effectiveness of Newer Antiepileptics: A Comparative Postmarketing Cohort Study
J Clin Pharmacol 2005 45: 385. [Abstract] [Full Text] [PDF]  

Review:

Eiichi Fuse, Takashi Kuwabara, Alex Sparreboom, Edward A. Sausville, and William D. Figg

Review of UCN-01 Development: A Lesson in the Importance of Clinical Pharmacology
J Clin Pharmacol 2005 45: 394. [Abstract] [Full Text] [PDF]  

Pharmacogenomics:

HongXia Zheng, Erin Schuetz, Adriana Zeevi, Jiong Zhang, Kenneth McCurry, Steven Webber, Aldo Iacono, Jatinder Lamba, and Gilbert J. Burckart

Sequential Analysis of Tacrolimus Dosing in Adult Lung Transplant Patients With ABCB1 Haplotypes
J Clin Pharmacol 2005 45: 404. [Abstract] [Full Text] [PDF]  

Drug Metabolism and Transport:

Wendy S. Putnam, Jonathan M. Woo, Yong Huang, and Leslie Z. Benet

Effect of the MDR1 C3435T Variant and P-Glycoprotein Induction on Dicloxacillin Pharmacokinetics
J Clin Pharmacol 2005 45: 411. [Abstract] [Full Text] [PDF]  

Drug Interactions:

Markus Jerling, Bee-Lian Huan, Kwan Leung, Nancy Chu, Hisham Abdallah, and Ziad Hussein

Studies to Investigate the Pharmacokinetic Interactions Between Ranolazine and Ketoconazole, Diltiazem, or Simvastatin During Combined Administration in Healthy Subjects
J Clin Pharmacol 2005 45: 422. [Abstract] [Full Text] [PDF]  

Pharmacokinetics and Pharmacodynamics:

Jing-He Yan, Kenneth Ataga, Sanjeev Kaul, Jeffery S. Olson, Dennis M. Grasela, Samantha Gothelf, Abdulah Kutlar, and Eugene Orringer

The Influence of Renal Function on Hydroxyurea Pharmacokinetics in Adults With Sickle Cell Disease
J Clin Pharmacol 2005 45: 434. [Abstract] [Full Text] [PDF]  

J. M. Kovarik, R. L. Schmouder, D. Serra, Y. Wang, H. Wiegand, S. C. Dilzer, and K. C. Lasseter

FTY720 Pharmacokinetics in Mild to Moderate Hepatic Impairment
J Clin Pharmacol 2005 45: 446. [Abstract] [Full Text] [PDF]  

Arani Chatterjee, Raghunadharao Digumarti, Kasiram Katneni, Vijay V. Upreti, Rao N. V. S. Mamidi, Ramesh Mullangi, Anjna Surath, Maddali L. Srinivas, Srihari Uppalapati, Sangeeta Jiwatani, and Nuggehally R. Srinivas

Safety, Tolerability, and Pharmacokinetics of a Capsule Formulation of DRF-1042, a Novel Camptothecin Analog, in Refractory Cancer Patients in a Bridging Phase I Study
J Clin Pharmacol 2005 45: 453. [Abstract] [Full Text] [PDF]  

Bernard Vrijens, Eric Tousset, Richard Rode, Richard Bertz, Steve Mayer, and John Urquhart

Successful Projection of the Time Course of Drug Concentration in Plasma During a 1-Year Period From Electronically Compiled Dosing-Time Data Used as Input to Individually Parameterized Pharmacokinetic Models
J Clin Pharmacol 2005 45: 461. [Abstract] [Full Text] [PDF]  

Yu-Nien Sun, Jian-Feng Lu, Amita Joshi, Peter Compton, Paul Kwon, and Rene A. Bruno

Population Pharmacokinetics of Efalizumab (Humanized Monoclonal Anti-CD11a Antibody) Following Long-Term Subcutaneous Weekly Dosing in Psoriasis Subjects
J Clin Pharmacol 2005 45: 468. [Abstract] [Full Text] [PDF]  

Brief Reports:

Maria Syka, Sophia L. Markantonis, Christos Mathas, and Nina Maggina

A Pilot Study of Netilmicin Pharmacokinetics During Continuous Venovenous Hemodiafiltration
J Clin Pharmacol 2005 45: 477. [Full Text] [PDF]  

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